Potassium Bis(trimethylsilyl)amide (KHMDS) CAS 40949-94-8 (0.5M Solution in Toluene)

Short Description:

Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene)

Synonyms: KHMDS

CAS: 40949-94-8

Content of Active Base: 0.45~0.55 M

Appearance: Yellow to Brown Liquid

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Product Detail

Product Tags

40949-94-8 - Description:

Ruifu Chemical is the leading manufacturer of Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene) (KHMDS) (CAS: 40949-94-8) with high quality. Ruifu Chemical can supply a series of active bases and Grignard reagents. Ruifu Chemical can provide worldwide delivery, small and bulk quantities available. If you are interested in KHMDS, please send detailed information includes CAS number, product name, quantity to us. Please contact: alvin@ruifuchem.com

Active Bases:

Potassium Bis(trimethylsilyl)amide	KHMDS	CAS 40949-94-8
Lithium Diisopropylamide	LDA	CAS 4111-54-0
Sodium Bis(trimethylsilyl)amide	NaHMDS	CAS 1070-89-9
Lithium Bis(trimethylsilyl)amide	LiHMDS	CAS 4039-32-1

40949-94-8 - Chemical Properties:

Chemical Name	Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene)
Synonyms	Hexamethyldisilazane Potassium Salt; Potassium Hexamethyldisilazane; KHMDS; 1,1,1,3,3,3-Hexamethyldisilazane Potassium Salt
CAS Number	40949-94-8
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C6H18KNSi2
Molecular Weight	199.49
Boiling Point	111℃
Density	0.877 g/mL at 25℃
Hazard Class	3 (8); Flammable Liquid, Corrosive
Solubility	Miscible With Terahydrofuran, Ether, Benzene and Toluene
Water Solubility	Reacts With Water
Hydrolytic Sensitivity	8: Reacts Rapidly With Moisture, Water, pProtic Solvents
Stability	Moisture Sensitive, Air Sensitive, Heat Sensitive. Store Under Nitrogen. May Form a Precipitate. Ambient Temperatures.
Safety	Hazardous-An Additional Dangerous Goods Freight Charge May Apply
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Active Bases
Brand	Ruifu Chemical

40949-94-8 - Specifications:

Item	Specifications	Results
Appearance	Yellow to Brown Liquid	Yellow Liquid
Other Impurities	≤3.00%	<3.00%
Content of Active Base	0.45~0.55 M	0.5 M
Test Standard	Enterprise Standard	Conforms

40949-94-8 - Package & Storage:

Package: Bottle, or according to customer's requirement.

Storage Condition: It is sensitive to moisture and air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Handle and store under inert gas. Incompatible with strong oxidizing agents.

Hazard Statements: Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. May cause drowsiness or dizziness.

40949-94-8 - Advantages:

40949-94-8 - FAQ:

40949-94-8 - Risk and Safety:

Risk Codes
R14 - Reacts violently with water
R34 - Causes burns
R67 - Vapors may cause drowsiness and dizziness
R65 - Harmful: May cause lung damage if swallowed
R63 - Possible risk of harm to the unborn child
R48/20 -
R11 - Highly Flammable
R40 - Limited evidence of a carcinogenic effect
R36/37/38 - Irritating to eyes, respiratory system and skin.
R19 - May form explosive peroxides
R37 - Irritating to the respiratory system
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label.
S43 - In case of fire use ... (there follows the type of fire-fighting equipment to be used.)
S46 - If swallowed, seek medical advice immediately and show this container or label.
S16 - Keep away from sources of ignition.
S36/37 - Wear suitable protective clothing and gloves.
UN IDs UN 3263 8/PG 3
WGK Germany 3
FLUKA BRAND F CODES 1-3-10
TSCA No
HS Code 2931900090
Hazard Class 3
Packing Group II

40949-94-8 - Application:

Potassium Bis(trimethylsilyl)amide (0.5M Solution in Toluene) (commonly abbreviated as KHMDS) (CAS: 40949-94-8) is a strong, non-nucleophilic base with an approximate pKa of 26 (compare to lithium diisopropylamide, at 36). It is commercially available as a solid and as a solution in a variety of solvents (ex. THF, 2Me-THF, toluene, and MTBE). Similar reagents include Lithium Bis(trimethylsilyl)amide (LiHMDS) and Sodium Bis(trimethylsilyl)amide (NaHMDS). Non-nucleophilic megasteric strong base. Pharmaceutical intermediates, used in the production of synthetic cephalosporins. KHMDS is a chemical reagent used in preparative high-performance liquid chromatography. KHMDS is used to form stable complexes with potassium, which are then separated by the column. KHMDS is also used in biochemical research and as an asymmetric synthesis catalyst. KHMDS is a strong base used in the alkylation carbonyl compounds. KHMDS is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.